Abstract
X chromosome inactivation is the epitome of epigenetic regulation and long non-coding ribonucleic acid function. The differentiation status of cells has been ascribed to X chromosome activity, with two active X chromosomes generally only observed in undifferentiated or poorly differentiated cells. Recently, several studies have indicated that the reactivation of an inactive X chromosome or X chromosome multiplication correlates with the development of malignancy; however, this concept is still controversial. This review sought to shed light on the role of the X chromosome in cancer development. In particular, there is a need for further exploration of the expression patterns of X-linked genes in cancer cells, especially those in head and neck squamous cell carcinoma (HNSCC), in order to identify different prognostic subpopulations with distinct clinical implications. This article proposes a functional relationship between the loss of the Barr body and the disproportional expression of X-linked genes in HNSCC development.
Publication Date
10-1-2018
First Page
389
Last Page
397
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Sharma, Deepti; Koshy, George; Gupta, Shruti; Sharma, Bhushan; and Grover, Sonal
(2018)
"Deciphering the Role of the Barr Body in Malignancy: An insight into head and neck cancer,"
Sultan Qaboos University Medical Journal: Vol. 17: 389-397.
DOI: https://doi.org/10.18295/squmj.2017.17.04.003
