Abstract
An intravenous (IV) administration of midazolam may result in seizure-like activity or movement. This report describes 5 neonates who developed seizure-like movements after IV midazolam injection. The patients presented between 2019 and 2022 and were admitted to a neonatal intensive care unit located within an academic centre in Muscat, Oman. The abnormal movements occurred shortly after IV bolus administration of midazolam. None of the patients experienced seizure-like movements after receiving midazolam infusions. The seizure-like movements were aborted either spontaneously or by antiseizure medications. In addition, seizure recurrence was not observed in any of the infants during the later stages of their treatment. Since this adverse effect might be related to the speed of the bolus administration, IV midazolam must be given as a slow bolus over 2–3 minutes followed by a slow flush of normal saline. To prevent midazolam's potential adverse effect on newborns, neonatal caregivers must be aware of it.
Article Type
Case Series
Publication Date
8-29-2024
First Page
394
Last Page
398
Creative Commons License
This work is licensed under a Creative Commons Attribution-No Derivative Works 4.0 International License.
Recommended Citation
Shaker, Heba; Al-Amrani, Fatema; and Al Mandhari, Hilal
(2024)
"Midazolam-Induced Seizure-Like Activity in Five Neonates: A case series,"
Sultan Qaboos University Medical Journal: Vol. 24: 394-398.
DOI: https://doi.org/10.18295/squmj.10.2023.063
