Effect of Adjuvant Vitamin D Therapy on Total Nasal Symptoms Score, IgE, and Eosinophil Levels in Allergic Rhinitis: A systematic review and meta-analysis

Authors

Rahmi Surayya, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Malikussaleh, Aceh Utara, IndonesiaFollow
Dwi R. Pawarti, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Rizka F. Perdana, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Citrawati D.K. Wungu, Department of Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Abstract

This review investigated the effects of adjuvant vitamin D therapy on Total Nasal Symptoms Score (TNSS), IgE, and eosinophil counts in patients with allergic rhinitis (AR). The meta-analysis used databases, such as PubMed, Science Direct, Scopus, Web of Science, SAGE journals, and clinicaltrials.gov. Quality appraisal was performed using RoB 2 and NOS tools. The research was guided by the PRISMA 2020 chart and analyzed using RevMan 5.4. Sixteen articles, including 11 randomised controlled trials and five cohorts, met the inclusion criteria. Fourteen articles reported TNSS, while four reported IgE and eosinophil levels. Vitamin D significantly reduced TNSS (SMD -2.24; 95% confidence interval [CI]: -3.05, -1.43; P < 0.00001; I2 = 96%), IgE (SMD -1.45; 95% CI: -2.07 to -0.983; P < 0.00001; I² = 79%), and eosinophil levels (SMD -2.20; 95% CI: -3.92 to -0.48; P = 0.01; I² = 97%) in AR patients. Vitamin D adjuvant therapy significantly alleviated nasal symptoms and reduced IgE and eosinophil levels in patients with AR.

Publication Date

9-24-2025

First Page

867

Last Page

875

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Surayya, Rahmi; Pawarti, Dwi R.; Perdana, Rizka F.; and Wungu, Citrawati D.K. (2025) "Effect of Adjuvant Vitamin D Therapy on Total Nasal Symptoms Score, IgE, and Eosinophil Levels in Allergic Rhinitis: A systematic review and meta-analysis," Sultan Qaboos University Medical Journal: Vol. 25: 867-875.
DOI: https://doi.org/10.18295/2075-0528.2910