The Effect of Proton Pump Inhibitors on Bone Mineralisation A Systematic Review with Focus on PHOSPHO1

Authors

Célia Baudin, Faculty of Dental Medicine, University of Porto (FMDUP), Rua Dr. Manuel Peireira da Silva, 4200-393 Porto, PortugalFollow
Ricardo Faria-Almeida, LAQV/REQUIMTE, Periodontology and Oral Surgery Department, Faculty of Dental Medicine, University of Porto (FMDUP), Rua Dr. Manuel Peireira da Silva, 4200-393 Porto, Portugal

Abstract

Objectives: Proton pump inhibitors (PPIs) are among the most widely prescribed drugs for long-term suppression of gastric acid. Though generally considered safe, increasing evidence links their use to altered bone metabolism. This systematic review investigates the hypothesis that PPI-induced inhibition on PHOSPHO1-a bone-specific phosphatase- impairs bone mineralisation. Methods: A systematic electronic search was conducted for experimental studies from January 2000 to January 2025. The screening and selection followed PRISMA guidelines. Results: Of 20 articles identified, 3 met the inclusion criteria: two in-vitro studies and one combining both in-vitro and in-vivo data. All three examined the effects of PPIs on bone formation and consistently reported significantly reduced minerallization capacity. Conclusion: The review suggests that PPIs appear to inhibit PHOSPHO1 activity, potentially impairing early-stage bone mineralisation. However, due to the limited number of studies, these findings should be interpreted with caution, and further research is warranted.

Publication Date

11-1-2025

First Page

974

Last Page

980

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Baudin, Célia and Faria-Almeida, Ricardo (2025) "The Effect of Proton Pump Inhibitors on Bone Mineralisation A Systematic Review with Focus on PHOSPHO1," Sultan Qaboos University Medical Journal: Vol. 25: 974-980.
DOI: https://doi.org/10.18295/2075-0528.2920