Effectiveness of Vaginal Magnesium Sulfate on Pain and Labor Duration: A systematic review and meta-analysis

Authors

Somayeh Makvandi, Menopause Andropause Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranFollow
Elham Manouchehri, Department of Midwifery, Faculty of Nursing and Midwifery, Mashhad Medical Sciences, Islamic Azad University, Mashhad, IranFollow
Mahdieh Razi, Department of Pediatrics, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, IranFollow
Samaneh Alinejad Mofrad, Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran AND School of Nursing, Faculty of Science, Medicine and Health, University of Wollongong, South Western Sydney Campus, AustraliaFollow
Mona Larki, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AND Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, IranFollow

Abstract

This systematic review and meta-analysis aimed to evaluate the effectiveness of vaginal magnesium sulfate (MgSO4) administration during labour. A comprehensive search was conducted across six databases up to 30 July 2024, and updated on 13 January 2025, with no restrictions on time, language, or geographical region. The risk of bias was assessed using the RoB 2 tool, and the certainty of evidence was evaluated using GRADEpro. A total of seven randomised controlled trials were included. The meta-analysis demonstrated that topical magnesium sulfate significantly increased cervical dilatation by 2.27 cm (95% confidence interval [CI]: 1.98 to 2.56; PPP

Publication Date

7-28-2025

First Page

697

Last Page

707

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Makvandi, Somayeh; Manouchehri, Elham; Razi, Mahdieh; Mofrad, Samaneh Alinejad; and Larki, Mona (2025) "Effectiveness of Vaginal Magnesium Sulfate on Pain and Labor Duration: A systematic review and meta-analysis," Sultan Qaboos University Medical Journal: Vol. 25: 697-707.
DOI: https://doi.org/10.18295/2075-0528.2885