Anorectal Complications in Acute Leukaemia: A retrospective analysis of clinical characteristics, management and outcomes in a tertiary care setting in Oman

Authors

Najwa Al Himali, Department of Pharmacy, Sultan Qaboos University Hospital, University Medical City, Muscat, OmanFollow
Murtadha Al Khabori, Department of Hematology, Omani National Center for Hematology and Marrow Transplantation, University Medical City, Muscat, Oman
Mohamed Al Huneini, Department of Hematology, Omani National Center for Hematology and Marrow Transplantation, University Medical City, Muscat, Oman

Abstract

Objectives: Anorectal complications are common and serious issues among patients with haematological malignancies, leading to significant morbidity and mortality. Limited data are available on their incidence, microbiology screening and management. This study aimed to improve the understanding of these complications in patients diagnosed with acute leukaemia in Oman. Methods: This retrospective study was conducted at Sultan Qaboos University Hospital, Muscat, Oman and included patients diagnosed with acute leukaemia who developed anorectal complications over the past decade (2015–2024). Results: A total of 100 patients were included in this study; 50% had acute myeloid leukaemia (AML), 35% had acute lymphoblastic leukaemia (ALL) and 36% were newly diagnosed. Of the 119 anorectal complications, fissures were the most common (n = 48/119). Only 19 patients had culture-proven anorectal infections, most commonly caused by Pseudomonas. Both the Surgery and Infectious Diseases teams were involved in management, especially for abscesses. The majority of patients were treated with meropenem (n = 44/176) and metronidazole (n = 39/176). The recurrence rate was 40% and found to be higher among AML patients. A total of 16% of the patients died within 30 days of diagnosing anorectal complications. But their mortality was indirectly related to the anorectal complications. Conclusion: Anorectal complications were prevalent among these patients, particularly in those with AML and were more common among newly diagnosed individuals. Fissures were the most frequently observed complication, while abscesses posed the most significant management challenge, requiring collaboration between Surgery and Infectious Diseases teams. Close monitoring of patients can facilitate early detection and intervention of these complications.

Publication Date

1-27-2026

First Page

77

Last Page

83

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Himali, Najwa Al; Khabori, Murtadha Al; and Huneini, Mohamed Al (2026) "Anorectal Complications in Acute Leukaemia: A retrospective analysis of clinical characteristics, management and outcomes in a tertiary care setting in Oman," Sultan Qaboos University Medical Journal: Vol. 26: 77-83.
DOI: https://doi.org/10.18295/2075-0528.2961