Genotypes and Allele Frequencies of Angiotensin Converting Enzyme (ACE) Insertion/deletion polymorphism among Omanis

Authors

Ali T. Al-Hinai, Departments of Medicine, College of Medicine & H Sc, Sultan Qaboos University, P.O.Box 35, Al-Khod-123, Sultanate of Oman.
Mohammed O. Hassan, Department of Physiology, College of Medicine & H Sc, Sultan Qaboos University, P.O.Box 35, Al-Khod-123, Sultanate of Oman.
Mehmet Simsek, Department of Biochemistry, College of Medicine & H Sc, Sultan Qaboos University, P.O.Box 35, Al-Khod-123, Sultanate of Oman.
Hameeda Al-Barwani, Department of Biochemistry, College of Medicine & H Sc, Sultan Qaboos University, P.O.Box 35, Al-Khod-123, Sultanate of Oman.
Riad Bayoumi, Department of Biochemistry, College of Medicine & H Sc, Sultan Qaboos University, P.O.Box 35, Al-Khod-123, Sultanate of Oman.

Abstract

Objective: To describe the angiotensin converting enzyme (ACE) genotype frequencies among Omani Arabs. Method: A polymerase chain reaction (PCR) test, based on separation of different size DNA fragments, was developed to test the presence or absence (polymorphism) of a small DNA deletion in the ACE gene. The subjects were 124 Omani Arab students of Sultan Qaboos University, Muscat. Results: The frequency of the I allele was 0.29, while that of the D allele was 0.71. The gene frequency distribution did not deviate from Hardy-Weinberg equilibrium. Conclusions: The frequency of D allele among Omanis is similar to that among other Arabs and Africans, but differs significantly from that among the Japanese and Chinese.

Publication Date

4-30-2002

First Page

25

Last Page

27

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Al-Hinai, Ali T.; Hassan, Mohammed O.; Simsek, Mehmet; Al-Barwani, Hameeda; and Bayoumi, Riad (2002) "Genotypes and Allele Frequencies of Angiotensin Converting Enzyme (ACE) Insertion/deletion polymorphism among Omanis," Sultan Qaboos University Medical Journal: Vol. 4: 25-27.
DOI: https://doi.org/10.18295/2075-0528.2594