Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis

Authors

Musbah O. M. Tanira, Departments of Pharmacology, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman.
Mehmet Simsek, Departments of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman.
Khalid Al Balushi, Departments of Pharmacology, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman.
Khulood Al Lawatia, Departments of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman.
Hameedah Al Barawani, Departments of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman.
Riad A. Bayoumi, Departments of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman.

Abstract

Objective: to determine the genotypes of arylamine N-acetyltransferase (NAT2) among 127 unrelated apparently healthy Omanis. Method: Identify the most common known polymorphisms of NAT*2 gene namely, G191A, C282T, C341T, C481T, G590A, A803G and G857A using PCR-RFLP analysis. Results: Eleven allele variants (3 alternative) and 30 different genotypes were determined. The commonest alleles were found to be NAT*5B, NAT2*6A and NAT*4 with corresponding frequencies of 0.362, 0.248 and 0.189 respectively. The overall frequency of rapid acetylator alleles was 0.25. Conclusion: A new allele variant containing G590A, C282T and T341C polymorphisms was found in one subject (was named NAT2*5J). The commonest genotypes were found to be 5B/5B, 5B/6A, 4/5B, 4/6A with frequencies 0.165, 0.157, 0.118, 0.110 and 0.079 respectively.

Publication Date

4-30-2003

First Page

9

Last Page

14

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Tanira, Musbah O. M.; Simsek, Mehmet; Balushi, Khalid Al; Lawatia, Khulood Al; Barawani, Hameedah Al; and Bayoumi, Riad A. (2003) "Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis," Sultan Qaboos University Medical Journal: Vol. 5: 9-14.
DOI: https://doi.org/10.18295/2075-0528.2602